Generic chemoprevention of hepatocellular carcinoma

Phytoestrogens and Hepatocellular Carcinoma Chemoprevention

Phytoestrogens Hepatocellular carcinoma Chemoprevention Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver and the third leading cause of cancer mortality worldwide. Statistically liver cancer is the fifth most common cancer in men and the 7th most common cancer in women. The major common risk factors for hepatocellular are hepatitis B (HBV) and hepatitis C vi...

Statins and Metformin for Chemoprevention of Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the sixth most common cancer and the second or third leading cause of death from cancer worldwide, with the uncertainty reflecting the paucity or absence of reliable and accurate estimates in high-incidence countries. Most HCC cases occur in hepatitis B virus (HBV) endemic areas such as East Asia and sub-Saharan Africa. However, the incidence of HCC has been in...

Hepatocellular Carcinoma in Sheep

Hepatocellular carcinoma in a sheep

At necropsy of a five-year-old sheep, a pear shaped, lobular yellow-brownish mass measuring about 12 ×15 × 20 cm was found to involve the right hepatic lobe. Microscopic examination revealed two trabecularand solid patterns of neoplastic hepatocytes. In solid pattern, there were numerous tumoral giant cells thatcontain one or more large hyperchromatic bizarre-shaped nuclei scattered among clust...

Preclinical studies of 166Ho-chitosan for treatment of hepatocellular carcinoma

Introduction: Recently, due to the special characteristics of 166Ho and chitosan, 166Ho-chitosan complex was developed for treatment of tumors such as hepatocellular carcinoma. This complex has been lately prepared with high radiochemical purity in our lab. The preclinical studies of the complex however should be performed to evaluate the tracer concentration in target and...